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Recombinant Human CSF3R protein, His-tagged

Cat.No. : CSF3R-7008H
Product Overview : Recombinant Human CSF3R aa. (Lys271~Arg428 (Accession # Q99062)) fused with N-terminal His tag was produced in E. coli cells.
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  • Gene Information
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Description : The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia.
Source : E. coli
Species : Human
Tag : His
Form : Freeze-dried powder
Molecular Mass : 19 kDa as determined by SDS-PAGE reducing conditions.
Protein length : Lys271~Arg428 (Accession # Q99062)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 6.7.
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as liquid form in Phosphate buffered saline(PBS), pH 7.4.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : CSF3R colony stimulating factor 3 receptor [ Homo sapiens (human) ]
Official Symbol : CSF3R
Synonyms : CSF3R; colony stimulating factor 3 receptor; SCN7; CD114; GCSFR; granulocyte colony-stimulating factor receptor; CD114 antigen; G-CSF receptor; G-CSF-R; colony stimulating factor 3 receptor (granulocyte)
Gene ID : 1441
mRNA Refseq : NM_000760.3
Protein Refseq : NP_000751.1
UniProt ID : Q99062

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In which conditions are CSF3R-targeted therapies currently being investigated? 11/22/2021

CSF3R-targeted therapies are under investigation for conditions such as chronic neutrophilic leukemia and other myeloproliferative neoplasms.

Are there specific diagnostic tests for CSF3R mutations? 08/11/2021

Yes, genetic testing and sequencing techniques are commonly employed to identify CSF3R mutations and guide clinical decision-making.

How do CSF3R mutations impact the prognosis of hematological disorders? 12/29/2019

The presence and specific type of CSF3R mutations can influence the prognosis of hematological disorders, guiding clinicians in predicting disease progression and response to treatment.

Can CSF3R mutations be hereditary? 04/12/2019

Yes, some CSF3R mutations can be hereditary, leading to familial cases of neutropenia.

How does understanding CSF3R protein function contribute to treatment strategies? 02/08/2018

Targeted therapies directed at CSF3R may offer more effective and tailored treatment options for patients with disorders related to abnormal granulocyte production.

Customer Reviews (3)

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Reviews
06/23/2019

    the CSF3R protein demonstrates exceptional stability, allowing for prolonged storage and usage without compromising its integrity.

    12/07/2018

      the protein's high quality ensures accurate and reliable results, enabling precise analysis and interpretation of experimental data.

      09/16/2018

        The manufacturer of the CSF3R protein plays a crucial role in supporting researchers during their trials.

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