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Recombinant Human CTCF protein, GST-tagged

Cat.No. : CTCF-16H
Product Overview : Recombinant Human CTCF(1 a.a. - 727 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.
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  • Gene Information
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Description : This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : Wheat Germ
Species : Human
Tag : GST
Form : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Molecular Mass : 105.6 kDa
AA Sequence : MEGDAVEAIVEESETFIKGKERKTY QRRREGGQEEDACHLPQNQTDGGEV VQDVNSSVQMVMMEQLDPTLLQMKT EVMEGTVAPEAEAAVDDTQIITLQV VNMEEQPINIGELQLVQVPVPVTVP VATTSVEELQGAYENEVSKEGLAES EPMICHTLPLPEGFQVVKVGANGEV ETLEQGELPPQEDPSWQKDPDYQPP AKKTKKTKKSKLRYTEEGKDVDVSV YDFEEEQQEGLLSEVNAEKVVGNMK PPKPTKIKKKGVKKTFQCELCSYTC PRRSNLDRHMKSHTDERPHKCHLCG RAFRTVTLLRNHLNTHTGTRPHKCP DCDMAFVTSGELVRHRRYKHTHEKP FKCSMCDYASVEVSKLKRHIRSHTG ERPFQCSLCSYASRDTYKLKRHMRT HSGEKPYECYICHARFTQSGTMKMH ILQKHTENVAKFHCPHCDTVIARKS DLGVHLRKQHSYIEQGKKCRYCDAV FHERYALIQHQKSHKNEKRFKCDQC DYACRQERHMIMHKRTHTGEKPYAC SHCDKTFRQKQLLDMHFKRYHDPNF VPAAFVCSKCGKTFTRRNTMARHAD NCAGPDGVEGENGGETKKSKRGRKR KMRSKKEDSSDSENAEPDLDDNEDE EEPAVEIEPEPEPQPVTPAPPPAKK RRGRPPGRTNQPKQNQPTAIIQVED QNTGAIENIIVEVKKEPDAEPAEGE EEEAQPAATDAPNGDLTPEMILSMM DR
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Gene Name : CTCF CCCTC-binding factor (zinc finger protein) [ Homo sapiens ]
Official Symbol : CTCF
Synonyms : CTCF; CCCTC-binding factor (zinc finger protein); transcriptional repressor CTCF; 11 zinc finger transcriptional repressor; CTCFL paralog; 11-zinc finger protein;
Gene ID : 10664
mRNA Refseq : NM_001191022
Protein Refseq : NP_001177951
MIM : 604167
UniProt ID : P49711

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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