| Description : |
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
104 kDa |
| AA Sequence : |
MMSQSSGSGDGNDDEATTSKDGGFS SPSPSAAAAAQEVRSATDGNTSTTP PTSAKKRKLNSSSSSSSNSSNERED FDSTSSSSSTPPLQPRDSASPSTSS FCLGVSVAASSHVPIQKKLRFEDTL EFVGFDAKMAEESSSSSSSSSPTAA TSQQQQLKNKSILISSVASVHHANG LAKSSTTVSSFANSKPGSAKKLVIK NFKDKPKLPENYTDETWQKLKEAVE AIQNSTSIKYNLEELYQAVENLCSY KISANLYKQLRQICEDHIKAQIHQF REDSLDSVLFLKKIDRCWQNHCRQM IMIRSIFLFLDRTYVLQNSMLPSIW DMGLELFRAHIISDQKVQNKTIDGI LLLIERERNGEAIDRSLLRSLLSML SDLQIYQDSFEQRFLEETNRLYAAE GQKLMQEREVPEYLHHVNKRLEEEA DRLITYLDQTTQKSLIATVEKQLLG EHLTAILQKGLNNLLDENRIQDLSL LYQLFSRVRGGVQVLLQQWIEYIKA FGSTIVINPEKDKTMVQELLDFKDK VDHIIDICFLKNEKFINAMKEAFET FINKRPNKPAELIAKYVDSKLRAGN KEATDEELEKMLDKIMIIFRFIYGK DVFEAFYKKDLAKRLLVGKSASVDA EKSMLSKLKHECGAAFTSKLEGMFK DMELSKDIMIQFKQYMQNQNVPGNI ELTVNILTMGYWPTYVPMEVHLPPE MVKLQEIFKTFYLGKHSGRKLQWQS TIGHCVLKAEFKEGKKELQVSLFQT LVLLMFNEGEEFSLEEIKQATGIED GELRRTLQSLACGKARVLAKNPKGK DIEDGDKFICNDDFKHKLFRIKINQ IQMKETVEEQASTTERVFQDRQYQI DAAIVRIMKMRKTLSHNLLVSEVYN QLKFPVKPADLKKRIESLIDRDYME RDKENPNQYNYIATRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
