Recombinant Human CUL4B protein, MYC/DDK-tagged

• Cat.No.: CUL4B-173H
• Product Overview: Recombinant Human CUL4B, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Description: This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 103.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: CUL4B cullin 4B [ Homo sapiens ]
• Official Symbol: CUL4B
• Synonyms: CUL4B; cullin 4B; cullin-4B; CUL-4B; SFM2; MRXSC; MRXHF2; MRXS15; KIAA0695; DKFZp686F1470
• Gene ID: 8450
• mRNA Refseq: NM_003588
• Protein Refseq: NP_003579
• MIM: 300304
• UniProt ID: Q13620
• Chromosome Location: Xq23
• Pathway: Cul4-DDB1-CSA complex, organism-specific biosystem; Cul4-DDB1-DDB2 complex, organism-specific biosystem; Nucleotide excision repair, organism-specific biosystem; Nucleotide excision repair, conserved biosystem; Ubiquitin mediated proteolysis, organism-specific biosystem; Ubiquitin mediated proteolysis, conserved biosystem
• Function: protein binding; ubiquitin protein ligase binding