| Description : |
Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
123.3 kDa |
| AA Sequence : |
MAPRKRGGRGISFIFCCFRNNDHPE ITYRLRNDSNFALQTMEPALPMPPV EELDVMFSELVDELDLTDKHREAMF ALPAEKKWQIYCSKKKDQEENKGAT SWPEFYIDQLNSMAARKSLLALEKE EEEERSKTIESLKTALRTKPMRFVT RFIDLDGLSCILNFLKTMDYETSES RIHTSLIGCIKALMNNSQGRAHVLA HSESINVIAQSLSTENIKTKVAVLE ILGAVCLVPGGHKKVLQAMLHYQKY ASERTRFQTLINDLDKSTGRYRDEV SLKTAIMSFINAVLSQGAGVESLDF RLHLRYEFLMLGIQPVIDKLREHEN STLDRHLDFFEMLRNEDELEFAKRF ELVHIDTKSATQMFELTRKRLTHSE AYPHFMSILHHCLQMPYKRSGNTVQ YWLLLDRIIQQIVIQNDKGQDPDST PLENFNIKNVVRMLVNENEVKQWKE QAEKMRKEHNELQQKLEKKERECDA KTQEKEEMMQTLNKMKEKLEKETTE HKQVKQQVADLTAQLHELSRRAVCA SIPGGPSPGAPGGPFPSSVPGSLLP PPPPPPLPGGMLPPPPPPLPPGGPP PPPGPPPLGAIMPPPGAPMGLALKK KSIPQPTNALKSFNWSKLPENKLEG TVWTEIDDTKVFKILDLEDLERTFS AYQRQQDFFVNSNSKQKEADAIDDT LSSKLKVKELSVIDGRRAQNCNILL SRLKLSNDEIKRAILTMDEQEDLPK DMLEQLLKFVPEKSDIDLLEEHKHE LDRMAKADRFLFEMSRINHYQQRLQ SLYFKKKFAERVAEVKPKVEAIRSG SEEVFRSGALKQLLEVVLAFGNYMN KGQRGNAYGFKISSLNKIADTKSSI DKNITLLHYLITIVENKYPSVLNLN EELRDIPQAAKVNMTELDKEISTLR SGLKAVETELEYQKSQPPQPGDKFV SVVSQFITVASFSFSDVEDLLAEAK DLFTKAVKHFGEEAGKIQPDEFFGI FDQFLQAVSEAKQENENMRKKKEEE ERRARMEAQLKEQRERERKMRKAKE NSEESGEFDDLVSALRSGEVFDKDL SKLKRNRKRITNQMTDSSRERPITK LNFTRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
