| Description : |
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
82.3 kDa |
| AA Sequence : |
MSNEVETSATNGQPDQQAAPKAPSK KEKKKGPEKTDEYLLARFKGDGVKY KAKLIGIDDVPDARGDKMSQDSMMK LKGMAAAGRSQGQHKQRIWVNISLS GIKIIDEKTGVIEHEHPVNKISFIA RDVTDNRAFGYVCGGEGQHQFFAIK TGQQAEPLVVDLKDLFQVIYNVKKK EEEKKKIEEASKAVENGSEALMILD DQTNKLKSGVDQMDLFGDMSTPPDL NSPTESKDILLVDLNSEIDTNQNSL RENPFLTNGITSCSLPRPTPQASFL PENAFSANLNFFPTPNPDPFRDDPF TQPDQSTPSSFDSLKSPDQKKENSS SSSTPLSNGPLNGDVDYFGQQFDQI SNRTGKQEAQAGPWPFSSSQTQPAV RTQNGVSEREQNGFSVKSSPNPFVG SPPKGLSIQNGVKQDLESSVQSSPH DSIAIIPPPQSTKPGRGRRTAKSSA NDLLASDIFAPPVSEPSGQASPTGQ PTALQPNPLDLFKTSAPAPVGPLVG LGGVTVTLPQAGPWNTASLVFNQSP SMAPGAMMGGQPSGFSQPVIFGTSP AVSGWNQPSPFAASTPPPVPVVWGP SASVAPNAWSTTSPLGNPFQSNIFP APAVSTQPPSMHSSLLVTPPQPPPR AGPPKDISSDAFTALDPLGDKEIKD VKEMFKDFQLRQPPVVPARKGEQTS SGTLSAFASYFNSKVGIPQENADHD DFDANQLLNKINEPPKPAPRQVSLP VTKSTDNAFENPFFKDSFGSSQASV ASSQPVSSEMYRDPFGNPFATRTRP LEQKLISEEDLAANDILDYKDDDDK V |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
