"DCXR" Related Products

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Recombinant Human DCXR protein, His-tagged

Cat.No.: DCXR-128H
Product Overview: Recombinant Human DCXR(1-244aa) fused with His tag at N-terminal was expressed in E. coli.
Description: Dicarbonyl/L-xylulose reductase, also known as DCXR, is an enzyme responsible for the metabolism of xylulose, converting it into xylitol. DCXR was expressed at low levels and was localized predominantly in the cytoplasmic membrane. In contrast, in virtually all grades of early-stage prostate cancer and in all chemohormonally treated cases, DCXR was strikingly overexpressed and was localized predominantly in the cytoplasm and nucleus.
Source: E. coli
Species: Human
Tag : His
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 50mM NaCl
Bio-activity: Specific activity is > 1,800 pmol/min/ug and is defined as the amount of enzyme that oxidize 1pmole of xylitol to L-xylulose per minute at pH 10.0 at 37°C.
Molecular Mass: 28 kDa (264aa), confirmed by MALDI-TOF
AA Sequence: MGSSHHHHHH SSGLVPRGSH MELFLAGRRV LVTGAGKGIG RGTVQALHAT GARVVAVSRT QADLDSLVRE CPGIEPVCVD LGDWEATERA
LGSVGPVDLL VNNAAVALLQ PFLEVTKEAF DRSFEVNLRA VIQVSQIVAR GLIARGVPGA IVNVSSQCSQ RAVTNHSVYC STKGALDMLT
KVMALELGPH KIRVNAVNPT VVMTSMGQAT WSDPHKAKTM LNRIPLGKFA EVEHVVNAIL FLLSDRSGMT TGSTLPVEGG FWAC
Purity: > 95% by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration: 0.5mg/ml (determined by Bradford assay)
Gene Name: DCXR dicarbonyl/L-xylulose reductase [ Homo sapiens ]
Official Symbol: DCXR
Synonyms: DCXR; dicarbonyl/L-xylulose reductase; L-xylulose reductase; DCR; KIDCR; SDR20C1; short chain dehydrogenase/reductase family 20C; member 1; carbonyl reductase 2; carbonyl reductase II; sperm surface protein P34H; kidney dicarbonyl reductase; short chain dehydrogenase/reductase family 20C, member 1; XR; HCR2; P34H; HCRII;
Gene ID: 51181
mRNA Refseq: NM_016286
Protein Refseq: NP_057370
MIM: 608347
UniProt ID: Q7Z4W1
Chromosome Location: 17q25.3
Pathway: D-glucuronate degradation I, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Pentose and glucuronate interconversions, organism-specific biosystem; Pentose and glucuronate interconversions, conserved biosystem;
Function: L-xylulose reductase (NADP+) activity; nucleotide binding; oxidoreductase activity, acting on CH-OH group of donors; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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