Recombinant Human DHPS, His-tagged

• Cat.No.: DHPS-26684TH
• Product Overview: Recombinant full length Human DHPS with a N terminal His tag. 389 amino acids with a predicted MWt 43.1 kDa including tag.

Specification

• Description: This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Protein length: 369 amino acids
• Conjugation: HIS
• Molecular Weight: 43.100kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 0.58% Sodium chloride, 20% Glycerol
• Storage: Please see Notes section
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MEGSLEREAP AGALAAVLKH SSTLPPESTQ VRGYDFNRGV NYRALLEAFG TTGFQATNFG RAVQQVNAMI EKKLEPLSQD EDQHADLTQS RRPLTSCTIF LGYTSNLISS GIRETIRYLV QHNMVDVLVT TAGGVEEDLI KCLAPTYLGE FSLRGKELRE NGINRIGNLL VPNENYCKFE DWLMPILDQM VMEQNTEGVK WTPSKMIARL GKEINNPESV YYWAQKNHIP VFSPALTDGS LGDMIFFHSY KNPGLVLDIV EDLRLINTQA IFAKCTGMII LGGGVVKHHI ANANLMRNGA DYAVYINTAQ EFDGSDSGAR PDEAVSWGKI RVDAQPVKVY ADASLVFPLL VAETFAQKMD AFMHEKNED
• Sequence Similarities: Belongs to the deoxyhypusine synthase family.

Gene Information

• Gene Name: DHPS deoxyhypusine synthase [ Homo sapiens ]
• Official Symbol: DHPS
• Synonyms: DHPS; deoxyhypusine synthase; MIG13; migration inducing gene 13
• Gene ID: 1725
• mRNA Refseq: NM_001206974
• Protein Refseq: NP_001193903
• MIM: 600944
• Uniprot ID: P49366
• Chromosome Location: 19p13.2
• Pathway: Hypusine synthesis from eIF5A-lysine, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Post-translational modification: gamma carboxylation and hypusine formation, organism-specific biosystem; Post-translational protein modification, organism-specific biosystem; hypusine biosynthesis, conserved biosystem
• Function: deoxyhypusine synthase activity; protein binding; transferase activity