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Recombinant Human DMPK Protein, GST-tagged

Cat.No. : DMPK-2708H
Product Overview : Human DMPK full-length ORF ( AAH62553, 1 a.a. - 629 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2016]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 94.93 kDa
AA Sequence : MSAEVRLRRLQQLVLDPGFLGLEPL LDLLLGVHQELGASELAQDKYVADF LQWAEPIVVRLKEVRLQRDDFEILK VIGRGAFSEVAVVKMKQTGQVYAMK IMNKWDMLKRGEVSCFREERDVLVN GDRRWITQLHFAFQDENYLYLVMEY YVGGDLLTLLSKFGERIPAEMARFY LAEIVMAIDSVHRLGYVHRDIKPDN ILLDRCGHIRLADFGSCLKLRADGT VRSLVAVGTPDYLSPEILQAVGGGP GTGSYGPECDWWALGVFAYEMFYGQ TPFYADSTAETYGKIVHYKEHLSLP LVDEGVPEEARDFIQRLLCPPETRL GRGGAGDFRTHPFFFGLDWDGLRDS VPPFTPDFEGATDTCNFDLVEDGLT AMVSGGGETLSDIREGAPLGVHLPF VGYSYSCMALRDSEVPGPTPMELEA EQLLEPHVQAPSLEPSVSPQDETAE VAVPAAVPAAEAEAEVTLRELQEAL EEEVLTRQSLSREMEAIRTDNQNFA SQLREAEARNRDLEAHVRQLQERME LLQAEGATAVTGVPSPRATDPPSHL DGPPAVAVGQCPLVGPGPMHRRHLL LPARVPRPGLSEALSLLLFAVVLSR AAALGCIGLVAHAGQLTAVWRRPGA ARAP
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : DMPK dystrophia myotonica-protein kinase [ Homo sapiens ]
Official Symbol : DMPK
Synonyms : DMPK; dystrophia myotonica-protein kinase; myotonin-protein kinase; DM; DM protein kinase; DM1; DM1PK; DMK; dystrophia myotonica 1; MDPK; MT PK; myotonic dystrophy associated protein kinase; myotonin protein kinase A; thymopoietin homolog; DM-kinase; DM1 protein kinase; myotonic dystrophy protein kinase; MT-PK;
Gene ID : 1760
mRNA Refseq : NM_001081563
Protein Refseq : NP_001075032
MIM : 605377
UniProt ID : Q09013

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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