Recombinant Human DNMT3A/DNMT3L Complex, His/GST-tagged DNMT3A/DNMT3L-0293H

Recombinant Human DNMT3A/DNMT3L Complex, His/GST-tagged

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Recombinant Human DNMT3A/DNMT3L Complex, His/GST-tagged

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Cat.No. : DNMT3A/DNMT3L-0293H
Product Overview : Recombinant Human DNMT3A(a.a 623-912) fused with His tag at N terminal and DNMT3L(a.a. 160-387) fused with GST tag at N terminal complex was co-expressed in a baculovirus-infected Sf9 cell expression system.
Source : Insect cells
Species : Human
Tag : His/GST
Form : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 16 mM glutathione and 20% glycerol.
Bio-activity : ≥0.58 pmol/min/µg.
Molecular Mass : DNMT3A: 34 kDa; DNMT3L: 52 kDa
Purity : > 95%
Applications : Useful for the study of DNA methylation, screening inhibitors, and selectivity profiling.
Storage : >6 months at –80 centigrade. Avoid freeze/thaw cycles.
Gene Name : DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha [ Homo sapiens ]
Official Symbol : DNMT3A
Synonyms : DNMT3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNA (cytosine-5)-methyltransferase 3A; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2; DNMT3A2; M.HsaIIIA;
Gene ID : 1788
mRNA Refseq : NM_175629
Protein Refseq : NP_783328
MIM : 602769
UniProt ID : Q9Y6K1
Chromosome Location : 2p23
Pathway : Cysteine and methionine metabolism, organism-specific biosystem; Cysteine and methionine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Methionine degradation, organism-specific biosystem; Methionine degradation, conserved biosystem; One Carbon Metabolism, organism-specific biosystem; Validated targets of C-MYC transcriptional repression, organism-specific biosystem;
Function : DNA (cytosine-5-)-methyltransferase activity; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates; DNA binding; chromatin binding; metal ion binding; methyltransferase activity; protein binding; transferase activity; unmethylated CpG binding;

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