Recombinant Human DNTT Protein, GST-His-tagged

• Cat.No.: DNTT-318H
• Product Overview: Recombinant Human DNTT, transcript variant 2, fused with N-terminal GST and C-terminal His was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: GST&His
• Description: This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
• Form: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.
• Molecular Mass: 84.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: DNTT deoxynucleotidyltransferase, terminal [ Homo sapiens ]
• Official Symbol: DNTT
• Synonyms: DNTT; deoxynucleotidyltransferase, terminal; DNA nucleotidylexotransferase; TDT; Terminal deoxynucleotidyltransferase; terminal transferase; terminal addition enzyme; terminal deoxynucleotidyltransferase; terminal deoxyribonucleotidyltransferase; nucleosidetriphosphate:DNA deoxynucleotidylexotransferase
• Gene ID: 1791
• mRNA Refseq: NM_001017520
• Protein Refseq: NP_001017520
• MIM: 187410
• UniProt ID: P04053