Recombinant Human DPYS, His-tagged

• Cat.No.: DPYS-12157H
• Product Overview: Recombinant Human DPYS protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: C-term-286a.a.
• Description: Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: DPYS dihydropyrimidinase [ Homo sapiens ]
• Official Symbol: DPYS
• Synonyms: DPYS; dihydropyrimidinase; DHPase; hydantoinase; dihydropyrimidine amidohydrolase; DHP
• Gene ID: 1807
• mRNA Refseq: NM_001385
• Protein Refseq: NP_001376
• MIM: 613326
• UniProt ID: Q14117
• Chromosome Location: 8q22
• Pathway: Drug metabolism - other enzymes, organism-specific biosystem; Drug metabolism - other enzymes, conserved biosystem; Fluoropyrimidine Activity, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Pantothenate and CoA biosynthesis, organism-specific biosystem
• Function: amino acid binding; dihydropyrimidinase activity; dihydropyrimidinase activity; dihydropyrimidinase activity; metal ion binding; phosphoprotein binding; thymine binding; uracil binding; zinc ion binding