Recombinant Human ECSIT Homolog (Drosophila), His-tagged
Cat.No. : | ECSIT-7177H |
Product Overview : | Recombinant human ECSIT protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 24.6 kDa. |
- Specification
- Gene Information
- Related Products
Description : | ECSIT is a ubiquitously expressed protein that plays an important role as an adaptor protein in the cytosolic signal transduction cascade events triggered by Toll receptor activation. It was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway. Knockdown of ECSIT results in severely impaired complex I assembly and disturbed mitochondrial function. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol,1mM DTT. |
Molecular Mass : | 24.6 kDa (222aa) confirmed by MALDI-TOF |
Protein length : | 19-217aa |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSGTCGAAL TGTSISQVPL PKDSTGAADP PQPHIVGIQS PDQQAALARH NPARPVFVEG PFSLWLRNKC VYYHILRADL LPPEEREVEE TPEEWNLYYP MQLDLEYVRS GWDNYEFDIN EVEEGPVFAM CMAGAHDQAT MAKWIQGLQE TNPTLAQIPV VFRLAGSTRE LQTSSAGLEE PPLPEDHQEE DDNLQRQQQG QS |
Purity : | >90% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Gene Name : | ECSIT ECSIT homolog (Drosophila) [ Homo sapiens ] |
Official Symbol : | ECSIT |
Synonyms : | ECSIT; ECSIT homolog (Drosophila); evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; signaling intermediate in Toll pathway evolutionarily conserved ortholog (mouse); SITPEC; likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved; |
Gene ID : | 51295 |
mRNA Refseq : | NM_001142464 |
Protein Refseq : | NP_001135936 |
MIM : | 608388 |
UniProt ID : | Q9BQ95 |
Chromosome Location : | 19p13.2 |
Pathway : | Activated TLR4 signalling, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem; MyD88 cascade initiated on plasma membrane, organism-specific biosystem; |
Function : | oxidoreductase activity, acting on NADH or NADPH; protein binding; |
Products Types
◆ Recombinant Protein | ||
ECSIT-3038H | Recombinant Human ECSIT Protein, GST-tagged | +Inquiry |
ECSIT-2631M | Recombinant Mouse ECSIT Protein, His (Fc)-Avi-tagged | +Inquiry |
Ecsit-2721M | Recombinant Mouse Ecsit Protein, Myc/DDK-tagged | +Inquiry |
ECSIT-922H | Recombinant Human ECSIT Protein, MYC/DDK-tagged | +Inquiry |
ECSIT-1664R | Recombinant Rat ECSIT Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ECSIT-241HCL | Recombinant Human ECSIT lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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