| Description : |
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
99.9 kDa |
| AA Sequence : |
MDVGEEPLEKAARARTAKDPNTYKV LSLVLSVCVLTTILGCIFGLKPSCA KEVKSCKGRCFERTFGNCRCDAACV ELGNCCLDYQETCIEPEHIWTCNKF RCGEKRLTRSLCACSDDCKDKGDCC INYSSVCQGEKSWVEEPCESINEPQ CPAGFETPPTLLFSLDGFRAEYLHT WGGLLPVISKLKKCGTYTKNMRPVY PTKTFPNHYSIVTGLYPESHGIIDN KMYDPKMNASFSLKSKEKFNPEWYK GEPIWVTAKYQGLKSGTFFWPGSDV EINGIFPDIYKMYNGSVPFEERILA VLQWLQLPKDERPHFYTLYLEEPDS SGHSYGPVSSEVIKALQRVDGMVGM LMDGLKELNLHRCLNLILISDHGME QGSCKKYIYLNKYLGDVKNIKVIYG PAARLRPSDVPDKYYSFNYEGIARN LSCREPNQHFKPYLKHFLPKRLHFA KSDRIEPLTFYLDPQWQLALNPSER KYCGSGFHGSDNVFSNMQALFVGYG PGFKHGIEADTFENIEVYNLMCDLL NLTPAPNNGTHGSLNHLLKNPVYTP KHPKEVHPLVQCPFTRNPRDNLGCS CNPSILPIEDFQTQFNLTVAEEKII KHETLPYGRPRVLQKENTICLLSQH QFMSGYSQDILMPLWTSYTVDRNDS FSTEDFSNCLYQDFRIPLSPVHKCS FYKNNTKVSYGFLSPPQLNKNSSGI YSEALLTTNIVPMYQSFQVIWRYFH DTLLRKYAEERNGVNVVSGPVFDFD YDGRCDSLENLRQKRRVIRNQEILI PTHFFIVLTSCKDTSQTPLHCENLD TLAFILPHRTDNSESCVHGKHDSSW VEELLMLHRARITDVEHITGLSFYQ QRKEPVSDILKLKTHLPTFSQEDTR TRPLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
