Recombinant Human EPHX2 Protein, His-tagged

• Cat.No.: EPHX2-584H
• Product Overview: Active human recombinant N-terminal His-tagged EPHX2 protein was purified from Sf21 cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Description: Mammalian soluble epoxide hydrolase (sEH) is a member of the α/β-hydrolase fold family of enzymes that catalyzes the hydrolysis of exogenous and endogenous epoxides to vicinal diols. sEH is a homodimer consisting of two domains. The C-terminal domain is responsible for the epoxide hydrolase activity while the N-terminal domain has a catalytic center with phosphatase activity. Endogenous substrates for sEH include epoxyeicosatrienoic acids (EETs) which are known for their vasodialatory effects as well as for their anti-inflammatory actions. Inhibition of sEH in animal models was shown to reduce hypertension and vascular inflammation, as well as related syndromes, validating sEH as a highly promising target for drug discovery.
• Molecular Mass: 64 kDa
• Purity: ≥95% estimated by SDS-PAGE
• Unit Definition: One unit hydrolyzes 1 nmol/min of PHOME at 37 centigrade. Detected by fluorescence of product; Ex. 330 nm, Em. 465 nm and measured against a standard curve of 6-methoxy-2-napthaldehyde.
• Notes: For research use only
• Stability: ≥ 6 months
• Storage: Store at -80 centigrade.
• Warning: This product is not for human or veterinary use.

Gene Information

• Gene Name: EPHX2 epoxide hydrolase 2 [ Homo sapiens (human) ]
• Official Symbol: EPHX2 epoxide hydrolase 2 [ Homo sapiens (human) ]
• Synonyms: EPHX2; epoxide hydrolase 2; Cytosolic Epoxide Hydrolase (CEH); EPHX2; Epoxide Hydrolase 2; sEH; CEH; SHE; bifunctional epoxide hydrolase 2; epoxide hydratase; epoxide hydrolase 2, cytoplasmic; epoxide hydrolase 2, cytosolic; epoxide hydrolase, soluble; EC 3.1.3.76; EC 3.3.2.10
• Gene ID: 2053
• mRNA Refseq: NM_001256482
• Protein Refseq: NP_001243411
• MIM: 132811
• UniProt ID: P34913