Recombinant Human ERN1 Protein, His-tagged

• Cat.No.: ERN1-1490H
• Product Overview: Recombinant Human ERN1 Protein (Phe571~Phe832) was expressed in E. coli with N-terminal His Tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 571-832 a.a.
• Description: This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.
• Form: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Molecular Mass: 33.3kDa
• Purity: > 97%
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.

Gene Information

• Gene Name: ERN1 endoplasmic reticulum to nucleus signaling 1 [ Homo sapiens (human) ]
• Official Symbol: ERN1
• Synonyms: IRE1; IRE1P; IRE1a; hIRE1p
• Gene ID: 2081
• mRNA Refseq: NM_001433.4
• Protein Refseq: NP_001424.3
• MIM: 604033
• UniProt ID: O75460