| Description : |
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
109.6 kDa |
| AA Sequence : |
MPARRLLLLLTLLLPGLGIFGSTST VTLPETLLFVSTLDGSLHAVSKRTG SIKWTLKEDPVLQVPTHVEEPAFLP DPNDGSLYTLGSKNNEGLTKLPFTI PELVQASPCRSSDGILYMGKKQDIW YVIDLLTGEKQQTLSSAFADSLCPS TSLLYLGRTEYTITMYDTKTRELRW NATYFDYAASLPEDDVDYKMSHFVS NGDGLVVTVDSESGDVLWIQNYASP VVAFYVWQREGLRKVMHINVAVETL RYLTFMSGEVGRITKWKYPFPKETE AKSKLTPTLYVGKYSTSLYASPSMV HEGVAVVPRGSTLPLLEGPQTDGVT IGDKGECVITPSTDVKFDPGLKSKN KLNYLRNYWLLIGHHETPLSASTKM LERFPNNLPKHRENVIPADSEKKSF EEVINLVDQTSENAPTTVSRDVEEK PAHAPARPEAPVDSMLKDMATIILS TFLLIGWVAFIITYPLSMHQQQQLQ HQQFQKELEKIQLLQQQQQQLPFHP PGDTAQDGELLDTSGPYSESSGTSS PSTSPRASNHSLCSGSSASKAGSSP SLEQDDGDEETSVVIVGKISFCPKD VLGHGAEGTIVYRGMFDNRDVAVKR ILPECFSFADREVQLLRESDEHPNV IRYFCTEKDRQFQYIAIELCAATLQ EYVEQKDFAHLGLEPITLLQQTTSG LAHLHSLNIVHRDLKPHNILISMPN AHGKIKAMISDFGLCKKLAVGRHSF SRRSGVPGTEGWIAPEMLSEDCKEN PTYTVDIFSAGCVFYYVISEGSHPF GKSLQRQANILLGACSLDCLHPEKH EDVIARELIEKMIAMDPQKRPSAKH VLKHPFFWSLEKQLQFFQDVSDRIE KESLDGPIVKQLERGGRAVVKMDWR ENITVPLQTDLRKFRTYKGGSVRDL LRAMRNKKHHYRELPAEVRETLGSL PDDFVCYFTSRFPHLLAHTYRAMEL CSHERLFQPYYFHEPPEPQPPVTPD ALTRTRPLEQKLISEEDLAANDILD YKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
