Recombinant Human FAM111B Protein, GST-tagged

• Cat.No.: FAM111B-3675H
• Product Overview: Human FAM111B full-length ORF ( ADR83393.1, 1 a.a. - 734 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a protein with a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A paralog of this gene which also has a trypsin‐like peptidase domain, FAM111A, is located only 16 kb from this gene on human chromosome 11q12.1. [provided by RefSeq, Apr 2014]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 80.8 kDa
• AA Sequence: MNSMKTEENKSFSAMEDDQRTRPEV SKDTVMKQTHADTPVDHCLSGIRKC SSTFKLKSEVNKHETALEMQNPNLN NKECCFTFTLNGNSRKLDRSVFTAY GKPSESIYSALSANDYFSERIKNQF NKNIIVYEEKTIDGHINLGMPLKCL PSDSHFKITFGQRKSSKEDGHILRQ CENPNMECILFHVVAIGRTRKKIVK INELHEKGSKLCIYALKGETIEGAL CKDGRFRSDIGEFEWKLKEGHKKIY GKQSMVDEVSGKVLEMDISKKKALQ QKDIHKKIKQNESATDEINHQSLIQ SKKKVHKPKKDGETKDVEHSREQIL PPQDLSHYIKDKTRQTIPRIRNYYF CSLPRKYRQINSQVRRRPHLGRRYA INLDVQKEAINLLKNYQTLNEAIMH QYPNFKEEAQWVRKYFREEQKRMNL SPAKQFNIYKKDFGKMTANSVSVAT CEQLTYYSKSVGFMQWDNNGNTGNA TCFVFNGGYIFTCRHVVHLMVGKNT HPSLWPDIISKCAKVTFTYTEFCPT PDNWFSIEPWLKVSNENLDYAILKL KENGNAFPPGLWRQISPQPSTGLIY LIGHPEGQIKKIDGCTVIPLNERLK KYPNDCQDGLVDLYDTTSNVYCMFT QRSFLSEVWNTHTLSYDTCFSDGSS GSPVFNASGKLVALHTFGLFYQRGF NVHALIEFGYSMDSILCDIKKTNES LYKSLNDEKLETYDEEKGKQESSLQ DHQIEPMEC
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FAM111B family with sequence similarity 111, member B [ Homo sapiens ]
• Official Symbol: FAM111B
• Synonyms: FAM111B; family with sequence similarity 111, member B; protein FAM111B; CANP; cancer-associated nucleoprotein
• Gene ID: 374393
• mRNA Refseq: NM_001142703
• Protein Refseq: NP_001136175
• MIM: 615584
• UniProt ID: Q6SJ93