Recombinant Human FASN protein, MYC/DDK-tagged FASN-138H

Recombinant Human FASN protein, MYC/DDK-tagged


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Recombinant Human FASN protein, MYC/DDK-tagged

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Cat.No. : FASN-138H
Product Overview : Recombinant Human FASN fused with MYC/DDK tag at C-terminal was expressed in HEK293.
Description : The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
Source : HEK293
Species : Human
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 273.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : FASN fatty acid synthase [ Homo sapiens ]
Official Symbol : FASN
Synonyms : FASN; fatty acid synthase; FAS; SDR27X1; short chain dehydrogenase/reductase family 27X; member 1; short chain dehydrogenase/reductase family 27X, member 1; OA-519; MGC14367; MGC15706;
Gene ID : 2194
mRNA Refseq : NM_004104
Protein Refseq : NP_004095
MIM : 600212
UniProt ID : P49327
Chromosome Location : 17q25
Pathway : ChREBP activates metabolic gene expression, organism-specific biosystem; Fatty Acid Biosynthesis, organism-specific biosystem; Fatty Acyl-CoA Biosynthesis, organism-specific biosystem; Fatty acid biosynthesis, organism-specific biosystem; Fatty acid biosynthesis, conserved biosystem; Fatty acid biosynthesis, elongation, organism-specific biosystem; Fatty acid biosynthesis, elongation, conserved biosystem;
Function : 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; [acyl-carrier-protein] S-acetyltransferase activity; [acyl-carrier-protein] S-malonyltransferase activity; acyl carrier activity; cofactor binding; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; fatty acid synthase activity; hydrolase activity, acting on ester bonds; lyase activity; myristoyl-[acyl-carrier-protein] hydrolase activity; nucleotide binding; oleoyl-[acyl-carrier-protein] hydrolase activity; oxidoreductase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; phosphopantetheine binding; protein binding; transferase activity; zinc ion binding;

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