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Recombinant Human FGFR2 protein(IIIb), His-Avi-tagged

Cat.No. : FGFR2-055H
Product Overview : Recombinant Human FGFR2 alpha (IIIb) Protein is expressed from mammalian with a His tag and Avi Tag at the C-terminal. It contains Arg22-Glu378.
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  • Gene Information
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Description : Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform.
Source : HEK293
Species : Human
Tag : His-Avi
Form : Supplied as 0. 22um filtered solution in PBS (pH 7. 4).
Molecular Mass : The protein has a predicted MW of 42. 5 kDa. Due to glycosylation, the protein migrates to 70-110KDa based on Bis-Tris PAGE result.
Protein length : It contains Arg22-Glu378.
Endotoxin : Less than 0. 05 EU per ug by the LAL method.
Purity : > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Storage : The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : FGFR2 fibroblast growth factor receptor 2 [ Homo sapiens ]
Official Symbol : FGFR2
Synonyms : FGF R2a; FGFR2 alpha;KGFR;CD332;Keratinocyte growth factor receptor
Gene ID : 2263
mRNA Refseq : NM_000141
Protein Refseq : NP_000132
MIM : 176943
UniProt ID : P21802

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is FGFR2 linked to developmental disorders? 01/01/2022

Mutations in FGFR2 are associated with various developmental disorders, impacting the development of the skull, limbs, and other structures.

Can FGFR2 be targeted for personalized cancer therapy? 04/19/2021

Yes, targeting FGFR2 mutations allows for more personalized and precise therapeutic approaches in cancer treatment.

Are there clinical trials involving FGFR2 inhibitors? 01/24/2020

Yes, numerous clinical trials are underway to evaluate the efficacy of FGFR2 inhibitors in treating various cancers and developmental disorders.

How does FGFR2 impact wound healing? 02/28/2019

FGFR2 is involved in the regulation of cell migration and tissue repair, contributing to the process of wound healing.

Are there any side effects associated with FGFR2 inhibitors? 08/28/2018

Common side effects of FGFR2 inhibitors include fatigue, nausea, and hypertension, which are being studied for better management.

Customer Reviews (3)

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Reviews
08/24/2017

    The FGFR2 protein is an outstanding product that possesses exceptional quality, making it an ideal choice for my experimental needs.

    03/05/2017

      What sets FGFR2 apart is the manufacturer's unparalleled technical support.

      09/13/2016

        The versatility of the FGFR2 protein makes it a valuable asset in my research.

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