| Description : |
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
54.6 kDa |
| AA Sequence : |
MYRALRLLARSRPLVRAPAAALASA PGLGGAAVPSFWPPNAARMASQNSF RIEYDTFGELKVPNDKYYGAQTVRS TMNFKIGGVTERMPTPVIKAFGILK RAAAEVNQDYGLDPKIANAIMKAAD EVAEGKLNDHFPLVVWQTGSGTQTN MNVNEVISNRAIEMLGGELGSKIPV HPNDHVNKSQSSNDTFPTAMHIAAA IEVHEVLLPGLQKLHDALDAKSKEF AQIIKIGRTHTQDAVPLTLGQEFSG YVQQVKYAMTRIKAAMPRIYELAAG GTAVGTGLNTRIGFAEKVAAKVAAL TGLPFVTAPNKFEALAAHDALVELS GAMNTTACSLMKIANDIRFLGSGPR SGLGELILPENEPGSSIMPGKVNPT QCEAMTMVAAQVMGNHVAVTVGGSN GHFELNVFKPMMIKNVLHSARLLGD ASVSFTENCVVGIQANTERINKLMN ESLMLVTALNPHIGYDKAAKIAKTA HKNGSTLKETAIELGYLTAEQFDEW VKPKDMLGPKTRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
