Recombinant Human FNIP2 Protein, His-tagged

• Cat.No.: FNIP2-171H
• Product Overview: Recombinant Human folliculin interacting protein 2(FNIP2), transcript variant 1(NM_020840), with a His tag, was expressed in human cells.

Specification

• Species: Human
• Source: Human Cells
• Tag: His
• Description: This gene encodes a member of the folliculin-interacting protein family. The encoded protein binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK) and be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This protein may also play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. A homologous binding partner of this protein, folliculin-interacting protein 1, has similar binding activities and may suggest functional redundancy within this protein family. Both folliculin-interacting proteins have also been shown to bind the molecular chaperone heat shock protein-90 (Hsp90) and they may function as a co-chaperones in the stabilization of tumor suppressor folliculin which is a target of Hsp90 chaperone activity.
• Form: Purified protein formulated in a sterile solution of TBS buffer, pH7.53, without any preservatives.
• Molecular Mass: 121.9 kDa
• Endotoxin: Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
• Purity: >90% by SDS-PAGE gel and Coomassie Blue staining
• Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies.

Gene Information

• Gene Name: FNIP2 folliculin interacting protein 2 [ Homo sapiens ]
• Official Symbol: FNIP2
• Synonyms: FNIP2; folliculin interacting protein 2; folliculin-interacting protein 2; FNIPL; KIAA1450; FNIP1-like protein; O6-methylguanine-induced apoptosis 1 protein; MAPO1
• Gene ID: 57600
• mRNA Refseq: NM_020840
• Protein Refseq: NP_065891
• MIM: 612768
• UniProt ID: Q9P278