Recombinant Human GABRA5 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: GABRA5-1352H
• Product Overview: GABRA5 MS Standard C13 and N15-labeled recombinant protein (NP_000801) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 52.15 kDa
• AA Sequence: MDNGMFSGFIMIKNLLLFCISMNLS SHFGFSQMPTSSVKDETNDNITIFT RILDGLLDGYDNRLRPGLGERITQV RTDIYVTSFGPVSDTEMEYTIDVFF RQSWKDERLRFKGPMQRLPLNNLLA SKIWTPDTFFHNGKKSIAHNMTTPN KLLRLEDDGTLLYTMRLTISAECPM QLEDFPMDAHACPLKFGSYAYPNSE VVYVWTNGSTKSVVVAEDGSRLNQY HLMGQTVGTENISTSTGEYTIMTAH FHLKRKIGYFVIQTYLPCIMTVILS QVSFWLNRESVPARTVFGVTTVLTM TTLSISARNSLPKVAYATAMDWFIA VCYAFVFSALIEFATVNYFTKRGWA WDGKKALEAAKIKKKREVILNKSTN AFTTGKMSHPPNIPKEQTPAGTSNT TSVSVKPSEEKTSESKKTYNSISKI DKMSRIVFPVLFGTFNLVYWATYLN REPVIKGAASPKSGPTRTRRLEQKL ISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 [ Homo sapiens (human) ]
• Official Symbol: GABRA5
• Synonyms: GABRA5; gamma-aminobutyric acid (GABA) A receptor, alpha 5; gamma-aminobutyric acid receptor subunit alpha-5; GABA(A) receptor; alpha 5; GABA(A) receptor, alpha 5; GABA(A) receptor subunit alpha-5; MGC138184
• Gene ID: 2558
• mRNA Refseq: NM_000810
• Protein Refseq: NP_000801
• MIM: 137142
• UniProt ID: P31644