Recombinant Human GAK Protein, Myc/DDK-tagged

• Cat.No.: GAK-01H
• Product Overview: Recombinant protein of human cyclin G associated kinase (GAK) protein with a C-Myc/DDK tag was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Molecular Mass: 143 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Gene Information

• Gene Name: GAK cyclin G associated kinase [ Homo sapiens (human) ]
• Official Symbol: GAK
• Synonyms: GAK; cyclin G associated kinase; DNAJ26; DNAJC26; cyclin-G-associated kinase; auxilin-2; EC 2.7.11.1
• Gene ID: 2580
• mRNA Refseq: NM_005255
• Protein Refseq: NP_005246
• MIM: 602052
• UniProt ID: O14976