| Description : |
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
143 kDa |
| AA Sequence : |
MSLLQSALDFLAGPGSLGGASGRDQ SDFVGQTVELGELRLRVRRVLAEGG FAFVYEAQDVGSGREYALKRLLSNE EEKNRAIIQEVCFMKKLSGHPNIVQ FCSAASIGKEESDTGQAEFLLLTEL CKGQLVEFLKKMESRGPLSCDTVLK IFYQTCRAVQHMHRQKPPIIHRDLK VENLLLSNQGTIKLCDFGSATTISH YPDYSWSAQRRALVEEEITRNTTPM YRTPEIIDLYSNFPIGEKQDIWALG CILYLLCFRQHPFEDGAKLRIVNGK YSIPPHDTQYTVFHSLIRAMLQVNP EERLSIAEVVHQLQEIAAARNVNPK SPITELLEQNGGYGSATLSRGPPPP VGPAGSGYSGGLALAEYDQPYGGFL DILRGGTERLFTNLKDTSSKVIQSV ANYAKGDLDISYITSRIAVMSFPAE GVESALKNNIEDVRLFLDSKHPGHY AVYNLSPRTYRPSRFHNRVSECGWA ARRAPHLHTLYNICRNMHAWLRQDH KNVCVVHCMDGRAASAVAVCSFLCF CRLFSTAEAAVYMFSMKRCPPGIWP SHKRYIEYMCDMVAEEPITPHSKPI LVRAVVMTPVPLFSKQRSGCRPFCE VYVGDERVASTSQEYDKMRDFKIED GKAVIPLGVTVQGDVLIVIYHARST LGGRLQAKMASMKMFQIQFHTGFVP RNATTVKFAKYDLDACDIQEKYPDL FQVNLEVEVEPRDRPSREAPPWENS SMRGLNPKILFSSREEQQDILSKFG KPELPRQPGSTAQYDAGAGSPEAEP TDSDSPPSSSADASRFLHTLDWQEE KEAETGAENASSKESESALMEDRDE SEVSDEGGSPISSEGQEPRADPEPP GLAAGLVQQDLVFEVETPAVLPEPV PQEDGVDLLGLHSEVGAGPAVPPQA CKAPSSNTDLLSCLLGPPEAASQGP PEDLLSEDPLLLASPAPPLSVQSTP RGGPPAAADPFGPLLPSSGNNSQPC SNPDLFGEFLNSDSVTVPPSFPSAH SAPPPSCSADFLHLGDLPGEPSKMT ASSSNPDLLGGWAAWTETAASAVAP TPATEGPLFSPGGQPAPCGSQASWT KSQNPDPFADLGDLSSGLQGSPAGF PPGGFIPKTATTPKGSSSWQTSRPP AQGASWPPQAKPPPKACTQPRPNYA SNFSVIGAREERGVRAPSFAQKPKV SENDFEDLLSNQGFSSRSDKKGPKT IAEMRKQDLAKDTDPLKLKLLDWIE GKERNIRALLSTLHTVLWDGESRWT PVGMADLVAPEQVKKHYRRAVLAVH PDKAAGQPYEQHAKMIFMELNDAWS EFENQGSRPLFSGPTRTRRLEQKLI SEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
