Recombinant Human GFI1, His-tagged

• Cat.No.: GFI1-13229H
• Product Overview: Recombinant Human GFI1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by mental retardation, language impairment, and behavioral disorders.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-422a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: GFI1 growth factor independent 1 transcription repressor [ Homo sapiens ]
• Official Symbol: GFI1
• Synonyms: GFI1; growth factor independent 1 transcription repressor; growth factor independent 1 , ZNF163; zinc finger protein Gfi-1; zinc finger protein 163; growth factor independence-1; growth factor independent protein 1; SCN2; GFI-1; ZNF163; FLJ94509
• Gene ID: 2672
• mRNA Refseq: NM_001127215
• Protein Refseq: NP_001120687
• MIM: 600871
• UniProt ID: Q99684
• Chromosome Location: 1p22
• Pathway: Validated targets of C-MYC transcriptional repression, organism-specific biosystem
• Function: DNA binding; metal ion binding; protein binding; transcription regulatory region DNA binding; zinc ion binding