"GFI1" Related Products

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Recombinant Human GFI1 protein, His-tagged

Cat.No.: GFI1-185H
Product Overview: Recombinant Human GFI1, transcript variant 1, fused with His tag at N-terminal was expressed in E. coli.
Description: This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.
Source: E. coli
Species: Human
Tag: His
Form: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Molecular Mass: 45.3 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Concentration: >50 ug/mL as determined by microplate BCA method
Gene Name: GFI1 growth factor independent 1 transcription repressor [ Homo sapiens ]
Official Symbol: GFI1
Synonyms: GFI1; growth factor independent 1 transcription repressor; growth factor independent 1 , ZNF163; zinc finger protein Gfi-1; zinc finger protein 163; growth factor independence-1; growth factor independent protein 1; SCN2; GFI-1; ZNF163; FLJ94509;
Gene ID: 2672
mRNA Refseq: NM_005263
Protein Refseq: NP_005254
MIM: 600871
UniProt ID: Q99684
Chromosome Location: 1p22
Pathway: Validated targets of C-MYC transcriptional repression, organism-specific biosystem;
Function: DNA binding; metal ion binding; protein binding; transcription regulatory region DNA binding; zinc ion binding;

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