Recombinant Human GHR, His-tagged, Biotinylated

Cat.No. : GHR-254H
Product Overview : Human GHR Protein, Biotinylated (Biotinylated GHR) Ala 27 - Tyr 264, was labeled with biotin based on rhGHR Protein, which was produced in human 293 cells (HEK293).
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Description : This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose are added as protectants before lyophilization.
Molecular Mass : Biotinylated GHR, fused with 6×His tag at the C-terminus, has a calculated MW of 28.5 kDa. The predicted N-terminus is Ala 27. DTT-reduced Protein migrates as 40-50 kDa due to glycosylation.
Endotoxin : Less than 1.0 EU per μg of the Biotinylated GHR by the LAL method.
Purity : >95% as determined by reduced SDS-PAGE.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).
Gene Name : GHR growth hormone receptor [ Homo sapiens ]
Official Symbol : GHR
Synonyms : GHR; growth hormone receptor; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein; GHBP;
Gene ID : 2690
mRNA Refseq : NM_000163
Protein Refseq : NP_000154
MIM : 600946
UniProt ID : P10912
Chromosome Location : 5p14-p12
Pathway : Androgen Receptor Signaling Pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endochondral Ossification, organism-specific biosystem; Growth hormone receptor signaling, organism-specific biosystem; Immune System, organism-specific biosystem;
Function : SH2 domain binding; growth factor binding; growth hormone receptor activity; peptide hormone binding; proline-rich region binding; protein binding; protein homodimerization activity; protein kinase binding; protein phosphatase binding; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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