Recombinant Human Ghrelin/Obestatin Prepropeptide, His-tagged

• Cat.No.: GHRL-5008H
• Product Overview: Recombinant Ghrelin protein, fused to His-tag, was expressed in E. coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: Human
• Tag: His
• Description: Ghrelin, also known as Obestatin, is the ligand for growth hormone secretagogue receptor type 1 (GHSR). It induces the release of growth hormone from the pituitary and involved in growth regulation. This protein has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Ghrelin plays a significant role in neurotrophy, particularly in the hippocampus, and is essential for cognitive adaptation to changing environments and the process of learning.
• Concentration: 1 mg/ml
• Form: Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol.
• Purity: > 90% by SDS - PAGE
• Sequence: 24-117 amino acids: MGSSHHHHHH SSGLVPRGSH MGSSFLSPEH QRVQQRKESK KPPAKLQPRA LAGWLRPEDG GQAEGAEDEM EVRFNAPFDV GIKLSGVQYQ QHSQALGKFL QDILWEEAKE APADK
• Molecular Mass: 12.8 kDa (115aa), confirmed by MALDI-TOF.
• Applications: SDS - PAGE
• Endotoxin Levels: < 1.0 EU per ug of protein (determined by LAL method )
• Storage: Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: GHRL ghrelin/obestatin prepropeptide [ Homo sapiens ]
• Official Symbol: GHRL
• Synonyms: GHRL; ghrelin/obestatin prepropeptide; MTLRP; obestatin; ghrelin/obestatin; OTTHUMP00000207794; OTTHUMP00000207795; OTTHUMP00000207796; OTTHUMP00000207798; motilin-related peptide; ghrelin/obestatin preprohormone; ghrelin, growth hormone secretagogue receptor ligand; ghrelin; Appetite-regulating hormone; M46 protein; Growth hormone secretagogue; Growth hormone-releasing peptide; Ghrelin-27; Ghrelin-28
• Gene ID: 51738
• mRNA Refseq: NM_001134941
• Protein Refseq: NP_001128413
• MIM: 605353
• UniProt ID: Q9UBU3
• Chromosome Location: 3p26-p25
• Pathway: Neuroactive ligand-receptor interaction
• Function: ghrelin receptor binding; growth hormone-releasing hormone activity; protein tyrosine kinase activator activity