Recombinant Human GIPC1, His-tagged

• Cat.No.: GIPC1-13265H
• Product Overview: Recombinant Human GIPC1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-333a.a.
• Description: Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.
• Source: E.coli
• Species: Human
• Tag: His
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: GIPC1 GIPC PDZ domain containing family, member 1 [ Homo sapiens ]
• Official Symbol: GIPC1
• Synonyms: GIPC1; GIPC PDZ domain containing family, member 1; C19orf3, chromosome 19 open reading frame 3 , regulator of G protein signalling 19 interacting protein 1 , RGS19IP1; PDZ domain-containing protein GIPC1; GIPC; GLUT1CBP; Hs.6454; NIP; SEMCAP; SYNECTIN; TIP 2; tax interaction protein 2; RGS19-interacting protein 1; RGS-GAIP-interacting protein; GLUT1 C-terminal binding protein; GAIP C-terminus-interacting protein; IGF-1 receptor interacting protein 1; regulator of G-protein signalling 19 interacting protein 1; IIP-1; TIP-2; C19orf3; RGS19IP1; SYNECTIIN; MGC3774; MGC15889
• Gene ID: 10755
• mRNA Refseq: NM_005716
• Protein Refseq: NP_005707
• MIM: 605072
• UniProt ID: O14908
• Chromosome Location: 19p13.1
• Pathway: Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem; Syndecan-4-mediated signaling events, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem
• Function: PDZ domain binding; actin binding; myosin binding; protein binding; protein homodimerization activity; receptor binding