Recombinant Human GLRA1 Protein, GST-tagged

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Recombinant Human GLRA1 Protein, GST-tagged

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Cat.No. : GLRA1-4970H
Product Overview : Human GLRA1 full-length ORF ( NP_000162.2, 1 a.a. - 449 a.a.) recombinant protein with GST-tag at N-terminal.
Description : The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Two transcript variants encoding different isoforms have been found for this gene
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 78.1 kDa
AA Sequence : MYSFNTLRLY LWETIVFFSL AASKEAEAAR SAPKPMSPSD FLDKLMGRTS GYDARIRPNF KGPPVNVSCN IFINSFGSIA ETTMDYRVNI FLRQQWNDPR LAYNEYPDDS LDLDPSMLDS IWKPDLFFAN EKGAHFHEIT TDNKLLRISR NGNVLYSIRI TLTLACPMDL KNFPMDVQTC IMQLESFGYT MNDLIFEWQE QGAVQVADGL TLPQFILKEE KDLRYCTKHY NTGKFTCIEA RFHLERQMGY YLIQMYIPSL LIVILSWISF WINMDAAPAR VGLGITTVLT MTTQSSGSRA SLPKVSYVKA IDIWMAVCLL FVFSALLEYA AVNFVSRQHK ELLRFRRKRR HHKEDEAGEG RFNFSAYGMG PACLQAKDGI SVKGANNSNT TNPPPAPSKS PEEMRKLFIQ RAKKIDKISR IGFPMAFLIF NMFYWIIYKI VRREDVHNQ
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : GLRA1 glycine receptor, alpha 1 [ Homo sapiens ]
Official Symbol : GLRA1
Synonyms : GLRA1; glycine receptor, alpha 1; glycine receptor, alpha 1 (startle disease/hyperekplexia), STHE; glycine receptor subunit alpha-1; startle disease/hyperekplexia; stiff person syndrome; glycine receptor 48 kDa subunit; glycine receptor strychnine-binding subunit; STHE; MGC138878; MGC138879;
Gene ID : 2741
mRNA Refseq : NM_000171
Protein Refseq : NP_000162
MIM : 138491
UniProt ID : P23415

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