Recombinant Human Glucagon
| Cat.No. : | GCG-295H |
| Product Overview : | Glucagon Like Peptide-2 contains 34 amino acids having a molecular mass of 3922.38 Dalton. |
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| Source : | Human |
| Tag : | Non |
| Description : | GLP-2 functions as an intestinal growth factor, which stimulates intestinal epithelial growth. GLP2 is involved in diabetes-associated bowel growth. GLP2 enhances cell differentiation, playing a role as a cytokine and in tissue regeneration, and mediating cytoprotection. GLP2 is invloded numerous therapeutic applications. GLP2 regulates signaling pathways coupled to cell proliferation and cell death by apoptosis. GLP-2 is produced by specific post-translational proteolytic cleavage of proglucagon GLP-2 is manufactured by the intestinal endocrine L cell and by several neurons in the central nervous system. |
| Form : | The protein (1mg/ml) was lyophilized with no additives. |
| Purity : | Greater than 95.0% as determined by RP-HPLC. |
| Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Solubility : | It is recommended to reconstitute the lyophilized GLP-2 in sterile 18Mμ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
| Amino acid sequence : | His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala- Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-Arg. |
| Storage : | Lyophilized GLP2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GLP2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Pathways : | Neuroactive ligand-receptor interaction; Diabetes pathways; Integration of energy metabolism; Signaling by GPCR |
| Gene Name | GCG glucagon [ Homo sapiens ] |
| Official Symbol | GCG |
| Synonyms | GCG; glucagon; GLP1; GLP2; GRPP; glucagon-like peptide 1; glucagon-like peptide 2; glicentin-related polypeptide |
| Gene ID | 2641 |
| mRNA Refseq | NM_002054 |
| Protein Refseq | NP_002045 |
| MIM | 138030 |
| UniProt ID | P01275 |
| Chromosome Location | 2q36-q37 |
| Function | hormone activity |
Not For Human Consumption!
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