Recombinant Human GNS Protein, GST-tagged

• Cat.No.: GNS-5101H
• Product Overview: Human GNS full-length ORF ( NP_002067.1, 1 a.a. - 552 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 88.5 kDa
• AA Sequence: MRLLPLAPGRLRRGSPRHLPSCSPA LLLLVLGGCLGVFGVAAGTRRPNVV LLLTDDQDEVLGGMTPLKKTKALIG EMGMTFSSAYVPSALCCPSRASILT GKYPHNHHVVNNTLEGNCSSKSWQK IQEPNTFPAILRSMCGYQTFFAGKY LNEYGAPDAGGLEHVPLGWSYWYAL EKNSKYYNYTLSINGKARKHGENYS VDYLTDVLANVSLDFLDYKSNFEPF FMMIATPAPHSPWTAAPQYQKAFQN VFAPRNKNFNIHGTNKHWLIRQAKT PMTNSSIQFLDNAFRKRWQTLLSVD DLVEKLVKRLEFTGELNNTYIFYTS DNGYHTGQFSLPIDKRQLYEFDIKV PLLVRGPGIKPNQTSKMLVANIDLG PTILDIAGYDLNKTQMDGMSLLPIL RGASNLTWRSDVLVEYQGEGRNVTD PTCPSLSPGVSQCFPDCVCEDAYNN TYACVRTMSALWNLQYCEFDDQEVF VEVYNLTADPDQITNIAKTIDPELL GKMNYRLMMLQSCSGPTCRTPGVFD PGYRFDPRLMFSNRGSVRTRRFSKH LL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: GNS glucosamine (N-acetyl)-6-sulfatase [ Homo sapiens ]
• Official Symbol: GNS
• Synonyms: GNS; glucosamine (N-acetyl)-6-sulfatase; N-acetylglucosamine-6-sulfatase; N acetylglucosamine 6 sulfatase; Sanfilippo disease IIID; glucosamine-6-sulfatase; G6S; MGC21274
• Gene ID: 2799
• mRNA Refseq: NM_002076
• Protein Refseq: NP_002067
• MIM: 607664
• UniProt ID: P15586