| Description : |
The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
75.8 kDa |
| AA Sequence : |
MREDHSFHVRYRMEASCLELALEGE RLCKSGDCRAGVSFFEAAVQVGTED LKTLSAIYSQLGNAYFYLHDYAKAL EYHHHDLTLARTIGDQLGEAKASGN LGNTLKVLGNFDEAIVCCQRHLDIS RELNDKVGEARALYNLGNVYHAKGK SFGCPGPQDVGEFPEEVRDALQAAV DFYEENLSLVTALGDRAAQGRAFGN LGNTHYLLGNFRDAVIAHEQRLLIA KEFGDKAAERRAYSNLGNAYIFLGE FETASEYYKKTLLLARQLKDRAVEA QSCYSLGNTYTLLQDYEKAIDYHLK HLAIAQELNDRIGEGRACWSLGNAY TALGNHDQAMHFAEKHLEISREVGD KSGELTARLNLSDLQMVLGLSYSTN NSIMSENTEIDSSLNGVRPKLGRRH SMENMELMKLTPEKVQNWNSEILAK QKPLIAKPSAKLLFVNRLKGKKYKT NSSTKVLQDASNSIDHRIPNSQRKI SADTIGDEGFFDLLSRFQSNRMDDQ RCCLQEKNCHTASTTTSSTPPKMML KTSSVPVVSPNTDEFLDLLASSQSR RLDDQRASFSNLPGLRLTQNSQSVL SHLMTNDNKEADEDFFDILVKCQGS RLDDQRCAPPPATTKGPTVPDEDFF SLILRSQGKRMDEQRVLLQRDQNRD TDFGLKDFLQNNALLEFKNSGKKSA DHTRTRPLEQKLISEEDLAANDILD YKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
