Recombinant Human GPT2 Protein, MYC/DDK-tagged

• Cat.No.: GPT2-2235H
• Product Overview: Recombinant human GPT2 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 57.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 [ Homo sapiens ]
• Official Symbol: GPT2
• Synonyms: ALT2
• Gene ID: 84706
• mRNA Refseq: NM_001142466
• Protein Refseq: NP_001135938
• MIM: 138210
• UniProt ID: Q8TD30