| Description : |
This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
57.9 kDa |
| AA Sequence : |
MQRAAALVRRGCGPRTPSSWGRSQS SAAAEASAVLKVRPERSRRERILTL ESMNPQVKAVEYAVRGPIVLKAGEI ELELQRGIKKPFTEVIRANIGDAQA MGQQPITFLRQVMALCTYPNLLDSP SFPEDAKKRARRILQACGGNSLGSY SASQGVNCIREDVAAYITRRDGGVP ADPDNIYLTTGASDGISTILKILVS GGGKSRTGVMIPIPQYPLYSAVISE LDAIQVNYYLDEENCWALNVNELRR AVQEAKDHCDPKVLCIINPGNPTGQ VQSRKCIEDVIHFAWEEKLFLLADE VYQDNVYSPDCRFHSFKKVLYEMGP EYSSNVELASFHSTSKGYMGECGYR GGYMEVINLHPEIKGQLVKLLSVRL CPPVSGQAAMDIVVNPPVAGEESFE QFSREKESVLGNLAKKAKLTEDLFN QVPGIHCNPLQGAMYAFPRIFIPAK AVEAAQAHQMAPDMFYCMKLLEETG ICVVPGSGFGQREGTYHFRMTILPP VEKLKTVLQKVKDFHINFLEKYASG PTRTRPLEQKLISEEDLAANDILDY KDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
