Recombinant Human GRK1

• Cat.No.: GRK1-27928TH
• Product Overview: Recombinant full length Human GRK1 with an N terminal proprietary tag, mol wt: 95 kDa.

Specification

• Description: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2).
• Protein length: 563 amino acids
• Molecular Weight: 95.000kDa
• Source: Baculovirus infected sf9 cells
• Tissue specificity: Retina and pineal gland.
• Biological activity: Specific activity: 4.3 nmol/min/mg
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 protein kinase domain.Contains 1 RGS domain.

Gene Information

• Gene Name: GRK1 G protein-coupled receptor kinase 1 [ Homo sapiens ]
• Official Symbol: GRK1
• Synonyms: GRK1; G protein-coupled receptor kinase 1; rhodopsin kinase , RHOK; rhodopsin kinase; GPRK1; RK
• Gene ID: 6011
• mRNA Refseq: NM_002929
• Protein Refseq: NP_002920
• MIM: 180381
• Uniprot ID: Q15835
• Chromosome Location: 13q34
• Pathway: Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Phototransduction, organism-specific biosystem
• Function: ATP binding; G-protein coupled receptor kinase activity; nucleotide binding; protein kinase activity; rhodopsin kinase activity