Recombinant Human Hexamethylene Bis-Acetamide Inducible 1, His-tagged

• Cat.No.: HEXIM1-5019H
• Product Overview: Recombinant HEXIM1 protein was expressed in E. coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: Human
• Tag: His
• Description: HEXIM1 is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This protein has been shown to form a protein-RNA complex composed of 7SK small nuclear RNA and positive transcription elongation factor b (P-TEFb), which is composed of cyclin-dependent kinase 9 (CDK9) and cyclin T1, and to inhibit the kinase activity of CDK9, thereby suppressing RNA polymerase II-dependent transcriptional elongation.
• Concentration: 0.5 mg/ml
• Form: Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol and 0.1M NaCl.
• Purity: > 90% by SDS - PAGE
• Sequence: 1-359 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMAE PFLSEYQHQP QTSNCTGAAA VQEELNPERP PGAEERVPEE DSRWQSRAFP QLGGRPGPEG EGSLESQPPP LQTQACPESS CLREGEKGQN GDDSSAGGDF PPPAEVEPTP EAELLAQPCH DSEASKLGAP AAGGEEEWGQ QQRQLGKKKH RRRPSKKKRH WKPYYKLTWE EKKKF
• Molecular Mass: 44.8 kDa (396aa), confirmed by MALDI-TOF.
• Applications: SDS-PAGE
• Storage: Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: HEXIM1 hexamethylene bis-acetamide inducible 1 [ Homo sapiens ]
• Official Symbol: HEXIM1
• Synonyms: hexamethylene bis-acetamide inducible 1; CLP1; EDG1; HIS1; MAQ1; FLJ13562; HEXIM1; protein HEXIM1; HMBA-inducible ; menage a quatre 1; cardiac lineage protein 1; menage a quatre protein 1; estrogen down-regulated gene 1 protein; hexamthylene bis-acetamide inducible 1; hexamethylene bisacetamide-inducible protein; hexamethylene bis-acetamide-inducible protein 1; hexamethylene-bis-acetamide-inducible transcript 1; CLP-1; HMBA-inducible; Estrogen down-regulated gene 1 protein; Cardiac lineage protein 1; Menage a quatre protein 1; Hexamethylene bis-acetamide-inducible protein 1
• Gene ID: 10614
• mRNA Refseq: NM_006460
• Protein Refseq: NP_006451
• MIM: 607328
• UniProt ID: O94992
• Chromosome Location: 17q21.31
• Function: cyclin-dependent protein kinase inhibitor activity; protein binding; snRNA binding; specific transcriptional repressor activity; transcription repressor activity