Recombinant Human HIV-1 Tat Interactive Protein 2, 30kDa, His-tagged

• Cat.No.: HTATIP2-2723H
• Product Overview: Recombinant humanHTATIP2 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 29.3 kDa (262aa),confirmed by MALDI-TOF.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: HTATIP2, also known as TIP30, is a member of the short-chain dehydrogenases/reductases (SDR) family. It acts as a tumor suppressor participating in metabolic suppression, inhibition of angiogenesis and induces the expression of apoptosis related genes Bad and Siva. HTATIP2 interacts with the activation domain of HIV-1 TAT and enhances its transcription by phosphorylating RNA polymerase II (Pol II). Defects in This protein are associated with hepatocellular carcinomas and apoptotic resistant tumor cells, suggesting a potential use for HTATIP2 in antitumor therapy.
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MAETEALSKL REDFRMQNKS VFILGASGET GRVLLKEILE QGLFSKVTLI GRRKLTFDEE AYKNVNQEVV DFEKLDDYAS AFQGHDVGFC CLGTTRGKAG AEGFVRVDRD YVLKSAELAK AGGCKHFNLL SSKGADKSSN FLYLQVKGEV EAKVEELKFD RYSVFRPGVL LCDRQESRPG EWLVRKFFGS LPDSWARGHS VPVVTVVRAM LNNVVRPRDK QMELLENKAI HDLGKAHGSL KP
• Form: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 1mM DTT.
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: HTATIP2 HIV-1 Tat interactive protein 2, 30kDa [ Homo sapiens ]
• Synonyms: HTATIP2; HIV-1 Tat interactive protein 2, 30kDa; oxidoreductase HTATIP2; Tat-interacting protein (30kD); HIV-1 TAT-interactive protein 2; 30 kDa HIV-1 TAT-interacting protein; short chain dehydrogenase/reductase family 44U, member 1; EC 1.1.1.-; CC3; TIP30; SDR44U1; FLJ26963
• Gene ID: 10553
• mRNA Refseq: NM_001098520
• Protein Refseq: NP_001091990
• MIM: 605628
• UniProt ID: Q9BUP3
• Chromosome Location: 11p15.1
• Function: NAD or NADH binding; RNA polymerase II transcription factor activity; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; protein binding; transcription coactivator activity