Recombinant Human HOMER1 Protein (Met1-Ser354), His tagged

• Cat.No.: HOMER1-3261H
• Product Overview: Recombinant human HOMER1 (Met1-Ser354) protein fused with His tag was expressed in E. coli.

Specification

• Description: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 40.61 kDa
• Protein Length: Met1-Ser354
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: HOMER1 homer homolog 1 (Drosophila) [ Homo sapiens (human) ]
• Official Symbol: HOMER1
• Synonyms: HOMER1; homer homolog 1 (Drosophila); homer protein homolog 1; HOMER 1B; SYN47; Ves 1; homer-1; homer, neuronal immediate early gene, 1; HOMER; Ves-1; HOMER1A; HOMER1B; HOMER1C
• Gene ID: 9456
• mRNA Refseq: NM_004272
• Protein Refseq: NP_004263
• MIM: 604798
• UniProt ID: Q86YM7