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Recombinant Human HUS1 Protein, GST-tagged

Cat.No. : HUS1-5225H
Product Overview : Human HUS1 full-length ORF ( AAH07013, 1 a.a. - 280 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 56.54 kDa
AA Sequence : MKFRAKIVDGACLNHFTRISNMIAK LAKTCTLRISPDKLNFILCDKLANG GVSMWCELEQENFFNEFQMEGVSAE NNEIYLELTSENLSRALKTAQNARA LKIKLTNKHFPCLTVSVELLSMSSS SRIVTHDIPIKVIPRKLWKDLQEPV VPDPDVSIYLPVLKTMKSVVEKMKN ISNHLVIEANLDGELNLKIETELVC VTTHFKDLGNPPLASESTHEDRNVE HMAEVHIDIRKLLQFLAGQQVNPTK ALCNIVNNKMVHFDLLHEDVSLQYF IPALS
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : HUS1 HUS1 checkpoint homolog (S. pombe) [ Homo sapiens ]
Official Symbol : HUS1
Synonyms : HUS1; HUS1 checkpoint homolog (S. pombe); HUS1 (S. pombe) checkpoint homolog; checkpoint protein HUS1; hus1+ like protein; hus1+-like protein; hHUS1;
Gene ID : 3364
mRNA Refseq : NM_004507
Protein Refseq : NP_004498
MIM : 603760
UniProt ID : O60921

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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