Recombinant Human IA2 Protein, GST-tagged

• Cat.No.: PTPRN-02H
• Product Overview: Recombinant human PTPRN protein with a GST-tag was expressed in E. coli

Specification

• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: GST
• Molecular Mass: The protein has a calculated MW of 68.6 kDa.
• AA Sequence: MSPILGYWKIKGLVQPTRLLLEYLE EKYEEHLYERDEGDKWRNKKFELGL EFPNLPYYIDGDVKLTQSMAIIRYI ADKHNMLGGCPKERAEISMLEGAVL DIRYGVSRIAYSKDFETLKVDFLSK LPEMLKMFEDRLCHKTYLNGDHVTH PDFMLYDALDVVLYMDPMCLDAFPK LVCFKKRIEAIPQIDKYLKSSKYIA WPLQGWQATFGGGDHPPKSDLVPRG SRQQDKERLAALGPEGAHGDTTFEY QDLCRQHMATKSLFNRAEGPPEPSR VSSVSSQFSDAAQASPSSHSSTPSW CEEPAQANMDISTGHMILAYMEDHL RNRDRLAKEWQALCAYQAEPNTCAT AQGEGNIKKNRHPDFLPYDHARIKL KVESSPSRSDYINASPIIEHDPRMP AYIATQGPLSHTIADFWQMVWESGC TVIVMLTPLVEDGVKQCDRYWPDEG ASLYHVYEVNLVSEHIWCEDFLVRS FYLKNVQTQETRTLTQFHFLSWPAE GTPASTRPLLDFRRKVNKCYRGRSC PIIVHCSDGAGRTGTYILIDMVLNR MAKGVKEIDIAATLEHVRDQRPGLV RSKDQFEFALTAVAEEVNAILKALP Q
• Purity: >95% by SDS-PAGE
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Lyophilized from 50mM Tris -HCI, 300mM NaCl, pH8.0

Gene Information

• Gene Name: PTPRN protein tyrosine phosphatase receptor type N [ Homo sapiens (human) ]
• Official Symbol: PTPRN
• Synonyms: PTPRN; protein tyrosine phosphatase receptor type N; IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP; receptor-type tyrosine-protein phosphatase-like N; ICA 512; PTP IA-2; insulinoma-associated tyrosine-phosphatase-like protein; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N; EC 3.1.3.48
• Gene ID: 5798
• mRNA Refseq: NM_002846
• Protein Refseq: NP_002837
• MIM: 601773
• UniProt ID: Q16849