| Description : |
Intercellular cell adhesion molecule-2 (CD102/ICAM-2) is a cell surface glycoprotein that belongs to the immunoglobulin superfamily (IgSF) of adhesion molecules. Like CD54/ICAM-1, CD102/ICAM-2 is a ligand that binds the leukocyte adhesion molecule LFA-1 (leukocyte function-associated antigen-1), which mediates intercellular interactions between immune cells and other cell types. Expression of CD102/ICAM-2 has been shown to affect angiogenesis, cellular radioresistance and anti-tumor immune response. Along with CD54/ICAM-1, CD102/ICAM-2 mediates T cell crawling and diapedesis across the blood-brain barrier, as well as T cell migration across the bronchial epithelium. CD102/ICAM-2 interaction with the actin cytoskeleton through α-actinin has been shown to limit the mobility on neuroblastoma cells, and this effect is dependent on glycosylation of CD102/ICAM-2. |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
His |
| Molecular Mass : |
~30 kDa |
| AA Sequence : |
KVFEVHVRPKKLAVEPKGSLEVNCS TTCNQPEVGGLETSLDKILLDEQAQ WKHYLVSNISHDTVLQCHFTCSGKQ ESMNSNVSVYQPPRQVILTLQPTLV AVGKSFTIECRVPTVEPLDSLTLFL FRGNETLHYETFGKAAPAPQEATAT FNSTADREDGHRNFSCLAVLDLMSR GGNIFHKHSAPKMLEIYEPVSDSQ |
| Purity : |
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
| Notes : |
For research use only, not for use in diagnostic procedure. |
| Storage : |
Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
| Storage Buffer : |
PBS, 4M Urea, pH7.4 |
