- Chicken(1)
- Human(21)
- Mouse(12)
- Rat(9)
- Rhesus(2)
- Rhesus Macaque(1)
- Rhesus monkey(3)
Recombinant Human ICOS (C136S, C137S) protein, His-tagged
Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.
Cat.No. : | ICOS-378H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Human ICOS protein (C136S, C137S, Glu21-Phe141), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293). |
Description : | Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278/ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 15.2 kDa. The protein migrates as 23-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | 121 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >85% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
SDS-PAGE of ICOS-378H : |
![]() Human ICOS (C136S, C137S), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 85%. |
Bioactivity-ELISA of ICOS-378H : |
![]() Immobilized Human B7-H2, Fc Tag at 1 μg/mL (100 μL/well) can bind Human ICOS (C136S, C137S), His Tag with a linear range of 0.008-0.125 μg/mL (QC tested). |
Gene Name : | ICOS |
Official Symbol : | ICOS |
Synonyms : | ICOS; inducible T-cell co-stimulator; inducible T-cell costimulator; activation inducible lymphocyte immunomediatory molecule; AILIM; CD278; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; CVID1; MGC39850 |
Gene ID : | 29851 |
mRNA Refseq : | NM_012092 |
Protein Refseq : | NP_036224 |
MIM : | 604558 |
UniProt ID : | Q9Y6W8 |
◆ Recombinant Protein
ICOS-1015R | Recombinant Rhesus ICOS Protein (Met1-Lys140), HlgG1 Fc-tagged | +Inquiry |
ICOS-827M | Recombinant Mouse ICOS Protein (Met1-Leu144), RlgG Fc-tagged | +Inquiry |
ICOS-2981R | Recombinant Rat ICOS Protein | +Inquiry |
Icos-1747M | Recombinant Mouse Inducible T-cell Co-stimulator | +Inquiry |
Icos-33M | Recombinant Mouse Icos protein, His-tagged | +Inquiry |
|
◆ Lysates
ICOS-1724MCL | Recombinant Mouse ICOS cell lysate | +Inquiry |
ICOS-1195RCL | Recombinant Rat ICOS cell lysate | +Inquiry |
ICOS-2444HCL | Recombinant Human ICOS cell lysate | +Inquiry |
|
Easy access to products and services you need from our library via powerful searching tools.
Copyright © 2023 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy