- Rhesus Macaque(1)
- Rhesus monkey(3)
Recombinant Human ICOS (C136S, C137S) protein, His-tagged
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|Cat.No. :||ICOS-378H Optional Service: Optional requirements on this protein|
|Product Overview :||Recombinant Human ICOS protein (C136S, C137S, Glu21-Phe141), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293).|
|Description :||Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278/ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.|
|Form :||Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose.|
|Molecular Mass :||The protein has a calculated MW of 15.2 kDa. The protein migrates as 23-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Protein length :||121|
|Endotoxin :||Less than 1.0 EU per ug by the LAL method.|
|Purity :||>85% as determined by SDS-PAGE.|
|Storage :||For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|SDS-PAGE of ICOS-378H :||
Human ICOS (C136S, C137S), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 85%.
|Bioactivity-ELISA of ICOS-378H :||
Immobilized Human B7-H2, Fc Tag at 1 μg/mL (100 μL/well) can bind Human ICOS (C136S, C137S), His Tag with a linear range of 0.008-0.125 μg/mL (QC tested).
|Gene Name :||ICOS|
|Official Symbol :||ICOS|
|Synonyms :||ICOS; inducible T-cell co-stimulator; inducible T-cell costimulator; activation inducible lymphocyte immunomediatory molecule; AILIM; CD278; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; CVID1; MGC39850|
|Gene ID :||29851|
|mRNA Refseq :||NM_012092|
|Protein Refseq :||NP_036224|
|UniProt ID :||Q9Y6W8|
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