Recombinant Human IDO2 protein, His-tagged

• Cat.No.: IDO2-22H
• Product Overview: Recombinant Human IDO2(15-420 aa) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 15-420 a.a.
• Description: Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).
• Form: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween- 20, 20% glycerol, 3 mM DTT and 150 mM imidazole.
• Molecular Mass: 46 kDa
• AA Sequence: MHHHHHHAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTE
  KSLLKEG
• Purity: > 90%
• Applications: Useful for studying enzyme kinetics, substrate specificity, and screening inhibitors.
• Storage: At least 6 months at –80 centigrade. Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary, use carrier protein (BSA 0.1 – 0.5%).

Gene Information

• Gene Name: IDO2 indoleamine 2,3-dioxygenase 2 [ Homo sapiens ]
• Official Symbol: IDO2
• Synonyms: IDO2; indoleamine 2,3-dioxygenase 2; INDOL1, indoleamine pyrrole 2,3 dioxygenase like 1; IDO-2; indoleamine 2,3-dioxygenase-like 1 protein; indoleamine 2,3-dioxygenase-like protein 1; indoleamine-pyrrole 2,3 dioxygenase-like 1; indoleamine-pyrrole 2,3-dioxygenase-like protein 1; INDOL1
• Gene ID: 169355
• mRNA Refseq: NM_194294
• Protein Refseq: NP_919270
• MIM: 612129
• UniProt ID: Q6ZQW0
• Chromosome Location: 8p11.21
• Pathway: African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Tryptophan catabolism, organism-specific biosystem; Tryptophan metabolism, organism-specific biosystem
• Function: heme binding; indoleamine 2,3-dioxygenase activity; indoleamine 2,3-dioxygenase activity; metal ion binding; oxidoreductase activity; tryptophan 2,3-dioxygenase activity