Recombinant Human IDO2 protein, His-tagged

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Recombinant Human IDO2 protein, His-tagged

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Cat.No. : IDO2-22H
Product Overview : Recombinant Human IDO2(15-420 aa) fused with His tag at N-terminal was expressed in E. coli.
Description : Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).
Source : E. coli
Species : Human
Tag : His
Form : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween- 20, 20% glycerol, 3 mM DTT and 150 mM imidazole.
Molecular Mass : 46 kDa
AA Sequence : MHHHHHHAHA MENSWTISKE YHIDEEVGFA LPNPQENLPD FYNDWMFIAK HLPDLIESGQ LRERVEKLNM LSIDHLTDHK SQRLARLVLG CITMAYVWGK GHGDVRKVLP RNIAVPYCQL SKKLELPPIL VYADCVLANW KKKDPNKPLT YENMDVLFSF RDGDCSKGFF LVSLLVEIAA ASAIKVIPTV FKAMQMQERD TLLKALLEIA SCLEKALQVF HQIHDHVNPK AFFSVLRIYL SGWKGNPQLS DGLVYEGFWE DPKEFAGGSA GQSSVFQCFD VLLGIQQTAG GGHAAQFLQD MRRYMPPAHR NFLCSLESNP SVREFVLSKG DAGLREAYDA CVKALVSLRS YHLQIVTKYI LIPASQQPKE NKTSEDPSKL EAKGTGGTDL MNFLKTVRST TE<br/>KSL LKEG
Purity : > 90%
Applications : Useful for studying enzyme kinetics, substrate specificity, and screening inhibitors.
Storage : At least 6 months at –80 centigrade. Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary, use carrier protein (BSA 0.1 – 0.5%).
Figure :

Gene Name : IDO2 indoleamine 2,3-dioxygenase 2 [ Homo sapiens ]
Official Symbol : IDO2
Synonyms : IDO2; indoleamine 2,3-dioxygenase 2; INDOL1, indoleamine pyrrole 2,3 dioxygenase like 1; IDO-2; indoleamine 2,3-dioxygenase-like 1 protein; indoleamine 2,3-dioxygenase-like protein 1; indoleamine-pyrrole 2,3 dioxygenase-like 1; indoleamine-pyrrole 2,3-dioxygenase-like protein 1; INDOL1;
Gene ID : 169355
mRNA Refseq : NM_194294
Protein Refseq : NP_919270
MIM : 612129
UniProt ID : Q6ZQW0
Chromosome Location : 8p11.21
Pathway : African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Tryptophan catabolism, organism-specific biosystem; Tryptophan metabolism, organism-specific biosystem;
Function : heme binding; indoleamine 2,3-dioxygenase activity; indoleamine 2,3-dioxygenase activity; metal ion binding; oxidoreductase activity; tryptophan 2,3-dioxygenase activity;

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