Recombinant Human IL17A & IL17F protein, His-Avi-tagged

• Cat.No.: IL17A & IL17F-01H
• Product Overview: Recombinant human IL17A&F Protein is expressed from mammalian with a His Tag and Avi Tag at the Cterminal. It contains Gly 24 - Ala 155 (IL-17A) & Arg31-Gln163 .

Specification

• Description: Interleukin‑17A (IL‑17A), also known as CTLA‑8, is a 15‑20 kDa glycosylated cytokine that plays an important role in anti‑microbial and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold .IL-17A is a ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC . Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines.
• Source: HEK293
• Species: Human
• Tag: His-Avi
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 18 kDa (Q16552-1) &15.9 kDa (Q96PD4).Due to glycosylation, the protein migrates to 16KDa&27KDa based on Bis-Tris PAGE result.
• Protein length: It contains Gly 24 - Ala 155 (IL-17A) & Arg31-Gln163.
• Endotoxin: Less than 0.01 EU per ug by the LAL method.
• Purity: > 95% as determined by Tris-Bis PAGE
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: IL17A interleukin 17A [ Homo sapiens ]
• Official Symbol: IL17A ; IL17F
• Synonyms: IL-17A,Interleukin-17A,CTLA-8,IL-17,IL-17F,IL24,ML-1,Interleukin-17F
• Gene ID: 3605
• mRNA Refseq: NM_002190
• Protein Refseq: NP_002181
• MIM: 603149
• UniProt ID: Q16552