Active Recombinant Cynomolgus/Rhesus IL23R protein, hFc-tagged

Cat.No. : IL23R-8493C
Product Overview : Recombinant Cynomolgus/Rhesus IL23R protein(F6XR82)(Met1-Asp353), fused with hFc tag, was expressed in HEK293.
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Source : HEK293
Species : Cynomolgus/Rhesus
Tag : hFc
Form : Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Bio-activity : Measured by its binding ability in a functional ELISA.1. Immobilized human IL23A-His+IL12B-His (Cat:CT012-H08H) at 10 μg/ml (100 μl/well) can bind Cynomolgus IL23R-Fc. The EC50 of Cynomolgus IL23R-Fc is 0.14-0.35 μg/ml.2.Immobilized mouse mIL12Bh (m)+mIL23Ah (Cat:CT028-M08H) at 10 μg/ml (100 μl/well) can bind Cynomolgus IL23R-Fc (Cat:90123-C02H). The EC50 of Cynomolgus IL23R-Fc (Cat:90123-C02H) is 0.05-0.11 μg/ml.
Molecular Mass : The recombinant cynomolgus / rhesus IL23R comprises 571 amino acids and has a calculated molecular mass of 64.9 KDa.
Protein Length : Met1-Asp353
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : > 90 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How does IL23R activation affect T-cell differentiation? 12/22/2022

IL23R activation promotes Th17 cell differentiation.

Does IL23R have alternative splicing variants? 02/20/2022

IL23R has multiple alternative splicing variants.

Does IL23R have any post-translational modifications that affect its stability? 08/23/2021

IL23R undergoes phosphorylation that affects its stability.

What is the half-life of IL23R protein in activated T-cells? 08/21/2020

The half-life of IL23R protein in activated T-cells is approximately 48 hours.

Are there any microRNAs that regulate IL23R expression? 06/16/2020

MicroRNAs like miR-20a regulate IL23R expression.

How does IL23R contribute to cytokine release? 02/15/2019

IL23R contributes to the release of pro-inflammatory cytokines like IL-17.

What role does IL23R play in autoimmune diseases? 08/22/2018

IL23R is implicated in autoimmune diseases like Crohn's.

How does IL23R expression change during infection? 10/12/2017

IL23R expression is upregulated during bacterial infection.

Does IL23R form homodimers or heterodimers? 08/15/2016

IL23R forms heterodimers with IL-12Rβ1.

What intracellular pathways are activated by IL23R? 08/06/2016

IL23R activates the JAK-STAT and NF-κB pathways.

Customer Reviews (3)

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Reviews
10/21/2020

    High specificity in ELISA.

    04/28/2016

      Effective in autoimmune models.

      03/30/2016

        Suitable for receptor binding studies.

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