Active Recombinant Cynomolgus IL23R protein, Fc-tagged

Cat.No. : IL23R-0271C
Product Overview : Recombinant Cynomolgus IL23R protein(Gly24-Asp353), fused with Fc tag, was expressed in HEK293.
  • Specification
  • Gene Information
  • Related Products
Source : HEK293
Species : Cynomolgus
Tag : Fc
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Bio-activity : Immobilized Biotinylated Human IL-23A&IL-12B Heterodimer Protein, His,Avitag&Tag Free at 1 μg/mL (100 μL/well) on streptavidin precoated (0.5 μg/well) plate can bind Cynomolgus IL-23 R, Fc Tag with a linear range of 0.1-3 ng/mL.
Molecular Mass : This protein carries a human IgG1 Fc tag at the C-terminusThe protein has a calculated MW of 64.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Proteinlength : Gly24-Asp353
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term, the product should be stored at lyophilized state at -20°C or lower.Please avoid repeated freeze-thaw cycles. This product is stable after at:
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Official Symbol : IL23R
Official Symbol : IL23R

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How does IL23R activation affect T-cell differentiation? 12/22/2022

IL23R activation promotes Th17 cell differentiation.

Does IL23R have alternative splicing variants? 02/20/2022

IL23R has multiple alternative splicing variants.

Does IL23R have any post-translational modifications that affect its stability? 08/23/2021

IL23R undergoes phosphorylation that affects its stability.

What is the half-life of IL23R protein in activated T-cells? 08/21/2020

The half-life of IL23R protein in activated T-cells is approximately 48 hours.

Are there any microRNAs that regulate IL23R expression? 06/16/2020

MicroRNAs like miR-20a regulate IL23R expression.

How does IL23R contribute to cytokine release? 02/15/2019

IL23R contributes to the release of pro-inflammatory cytokines like IL-17.

What role does IL23R play in autoimmune diseases? 08/22/2018

IL23R is implicated in autoimmune diseases like Crohn's.

How does IL23R expression change during infection? 10/12/2017

IL23R expression is upregulated during bacterial infection.

Does IL23R form homodimers or heterodimers? 08/15/2016

IL23R forms heterodimers with IL-12Rβ1.

What intracellular pathways are activated by IL23R? 08/06/2016

IL23R activates the JAK-STAT and NF-κB pathways.

Customer Reviews (3)

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Reviews
10/21/2020

    High specificity in ELISA. -

    04/28/2016

      Effective in autoimmune models. -

      03/30/2016

        Suitable for receptor binding studies. -

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