Recombinant Human IL8

• Cat.No.: IL8-27457TH
• Product Overview: Recombinant full length human IL8; 77 amino acids, 8.9 kDa.

Specification

• Description: The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.
• Source: E. coli
• Biological activity: Biological Activity:Specific Activity of IL8 in chemotaxis of donor PBL neutrophils, threshold concentration corresponding to 25-150ng/ml.
• Form: Lyophilised:Reconstitute in sterile 18MO-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.Upon reconstitution IL8-27457TH should be stored at 4°C between 2-7 days and for future use below -18°C. For long term sto
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: ddH20
• Storage: Lyophilized protein should be stored below -20°C. Upon reconstitution aliquot and store below -18°C to prevent freeze-thaw cycles.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
• Sequences of amino acids: The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Ala-Lys-Glu-Leu.
• Sequence Similarities: Belongs to the intercrine alpha (chemokine CxC) family.

Gene Information

• Gene Name: IL8 interleukin 8 [ Homo sapiens ]
• Official Symbol: IL8
• Synonyms: IL8; interleukin 8; interleukin-8; 3 10C; alveolar macrophage chemotactic factor I; AMCF I; b ENAP; beta endothelial cell derived neutrophil activating peptide; chemokine (C X C motif) ligand 8; CXCL8; GCP 1; GCP1; granulocyte chemotactic protein 1; IL 8
• Gene ID: 3576
• mRNA Refseq: NM_000584
• Protein Refseq: NP_000575
• MIM: 146930
• Uniprot ID: P10145
• Chromosome Location: 4q13-q21
• Pathway: ATF-2 transcription factor network, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem
• Function: chemokine activity; interleukin-8 receptor binding; protein binding