Recombinant Human INPP5B

• Cat.No.: INPP5B-27623TH
• Product Overview: Recombinant full length Human INPP5B with N terminal proprietary tag. Predicted MW 108.35 kDa.

Specification

• Description: Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
• Protein length: 748 amino acids
• Molecular Weight: 108.350kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Platelets.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVR YRLEHGGQEHALFLYTHRRMAITGDDVSLDQIVPVSRDFT LEEVSPDGELYILGSDVTVQLDTAELSLVFQLPFGSQTRM FLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPR GCNSALVTWPGYATIGGGGSNFDGLRPNGKGVPMDQSSRG QDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQK FGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPK ECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEE EWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAY ISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSH LAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHD VILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKI QVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAP AWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGV RVVNDELYRKTLEEIVRSLDKMENANIPSVSLSKREFCFQ NVKYMQLKVESFTIHNGQVPCHFEFINKPDEESYCKQWLN ANPSRGFLLPDSDVEIDLELFVNKTTATKLNSGEDKIEDI LVLHLDRGKDYFLSVSGNYLPSCFGSPIHTLCYMREPILD LPLETISELLAYLAAYCFETQLVTKSLI
• Sequence Similarities: Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family.Contains 1 Rho-GAP domain.

Gene Information

• Gene Name: INPP5B inositol polyphosphate-5-phosphatase, 75kDa [ Homo sapiens ]
• Official Symbol: INPP5B
• Synonyms: INPP5B; inositol polyphosphate-5-phosphatase, 75kDa; inositol polyphosphate 5 phosphatase, 75kD; type II inositol-1,4,5-trisphosphate 5-phosphatase
• Gene ID: 3633
• mRNA Refseq: NM_005540
• Protein Refseq: NP_005531
• MIM: 147264
• Uniprot ID: P32019
• Chromosome Location: 1p34
• Pathway: 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), conserved biosystem; 3-phosphoinositide degradation, conserved biosystem; D-myo-inositol (1,3,4)-trisphosphate biosynthesis, conserved biosystem; D-myo-inositol (1,4,5)-trisphosphate degradation, conserved biosystem; Inositol phosphate metabolism, organism-specific biosystem
• Function: hydrolase activity; inositol-polyphosphate 5-phosphatase activity; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; protein binding